It can be difficult to establish what constitutes a normal poisonous or lethal dose. Nevertheless, the lethal oral dose of codeine in an Grownup is reported to be while in the array of 0.

The drug is excreted principally while in the urine, largely as inactive metabolites and little quantities of absolutely free and conjugated morphine. Negligible amounts of codeine and its metabolites are found in the feces.

Promethazine is undoubtedly an H1 receptor blocking agent. Besides its antihistaminic motion, it offers clinically practical sedative and antiemetic consequences.

Codeine in oral therapeutic dosage does not usually exert main outcomes on the cardiovascular program.

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Parenteral drug abuse is commonly associated with transmission of infectious illnesses including hepatitis and HIV.

Due to the risks of habit, abuse, and misuse with opioids, even at advisable doses [see Warnings and Precautions (five.one)], reserve Promethazine HCl and Codeine Phosphate Oral Option for use in Grownup clients for whom the many benefits of Promethazine codeine syrup cough suppression are predicted to outweigh the hazards, As well as in whom an adequate evaluation of your etiology with the cough is made.

Nevertheless, codeine need to be administered only under near supervision to sufferers using a historical past of drug abuse or dependence.

Thing to consider should be presented for the discontinuation of promethazine HCl and also to the use of other medicines if these reactions manifest. Respiratory depression, nightmares, delirium, and agitated actions have also been documented in Some people.

Will not improve your dose or use this merchandise a lot more usually or for extended than prescribed. Your ailment will not likely improve any quicker, plus your threat of Unwanted side effects will raise.

Promethazine hydrochloride was not mutagenic during the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.

The majority of research examining the use of promethazine in pregnancy did not discover an association with an elevated chance of congenital anomalies. From the few reports reporting an association, no reliable sample of malformations was pointed out.

If another person has overdosed and it has critical indicators including passing out or trouble respiratory, connect with 911. Otherwise, contact a poison control Heart right away.

The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers under 6 yrs of age, for the reason that The mixture may perhaps cause fatal respiratory melancholy In this particular age populace. It's important that promethazine with codeine syrup is calculated with the accurate measuring system (see PRECAUTIONS-Information For Individuals).